When it comes to managing mental health conditions medicine is one of the best options. Anxiety and depression are common mental health problems in the USA. For treatment of these disorders, doctors commonly prescribe Trazodone and Xanax. Taking them together can increase the risk of dependence and side effects. Today, we understand these two medicines and whether is it safe to take trazodone and Xanax together.

Before discussing anything we need to know what is Xanax and Trazodone.

What Are They?

What is Trazodone–Trazodone is an antidepressant belonging to a class of medications called serotonin modulators. The brand name of this medicine is Desyrel which is no longer available in some countries. It works by increasing the level of serotonin, a neurotransmitter in the brain that helps improve mood. Sometimes it is used for off-label use to relieve the symptoms of post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and chronic pain conditions.

What is Xanax— Xanax (alprazolam) is a benzodiazepine that works by increasing the effect of gamma-aminobutyric acid (GABA), a neurotransmitter that serves as a calming agent in the brain. It is used to treat anxiety and panic attacks. However, due to its potential for dependence and abuse, it is generally recommended for short-term use.

Is Trazodone And Xanax The Same Thing

No, Xanax and Trazodone are not the same thing. One medicine is an antidepressant and sleep aid, while the other is an anti-anxiety medicine. However, both can be used to treat anxiety, depression, and insomnia. They are prescribed for different conditions and have different active ingredients, mechanisms of action, and potential side effects and risks. These medicines work on the different neurotransmitters in the brain to reduce anxiety and create a calming effect which leads to enhanced mood. Sometimes doctors prescribe trazodone and Xanax together for sleep. Consult with your doctor to know which medicines are suitable for you.

Difference Between Alprazolam And Trazodone

We all know that Xanax and Trazodone are two different prescription medicines used to treat mental health disorders like anxiety. The differences between the two drugs are:


  • Alprazolam, commonly known by the brand name Xanax belongs to the benzodiazepine family of drugs.
  • Prescribed to treat anxiety and panic disorders.
  • It works by enhancing the effect of the neurotransmitter called GABA in the brain which has a calming and sedative effect that leads to promoting mood.
  • It is a fast-acting medication that can provide quick relief from anxiety symptoms which is why used for short-term treatment.
  • Extended use may lead to dependence and withdrawal symptoms.


  • Trazodone is an antidepressant drug that belongs to the Serotonin antagonist and reuptake inhibitor (SARI) class.
  • Its primary use is for treating symptoms of depression and anxiety, although it can also be prescribed off-label to treat insomnia in individuals experiencing difficulty sleeping.
  • It works by modulating the levels of certain neurotransmitters in the brain, known as serotonin. It is a sedating medication, which is why it is often used to help insomnia in patients.
  • It is not addictive medicine and does not carry the risk of dependence and withdrawal.
  • The doctor prescribed this medicine for long-term use.

Trazodone and Alprazolam Interactions

When comes to the interaction between any two drugs they can have either a positive effect or a negative effect on one another. This positive interaction can be very effective for your anxiety symptoms and the negative effect may lead to increased sedation, drowsiness, and other side effects. Here are some interactions between trazodone and Xanax:

  • Increased Sedation: Both medicines have sedative properties when taken together these medicines can enhance each other sedative effects. This can increase drowsiness and affect your alertness ability which leads to road accidents.
  • Respiratory Depression: They work in the brain and if you take a higher dose of this medicine or their combination can lead to respiratory depression.
  • Memory impairment: Combining these medicines can lead to cognitive and memory impairment which can affect your thinking, coordination, and memory. You face difficulties in your daily life.
  • Polysubstance Addiction: when a person takes two or more medicines at a time and is addicted to them. If you suddenly stop taking these medicines then you will experience withdrawal symptoms.
  • Dependence and Withdrawal: Both medicines have the potential for dependence and withdrawal. Taking them together may increase the risk of dependence and withdrawal symptoms.
  • Heightened chance of Overdose: If you take this combination and increase any one medicine dose then it can be high the chance of overdose which leads to serious health consequences like coma and death.

Only a healthcare professional should guide and supervise the combination of Trazodone and Xanax. If your doctor or healthcare expert prescribes these medicines together after checking your health condition, medical history, or currently taken medicines then strictly follow the prescribed dosages. Never self-adjust your doses or without permission never stop taking them.

Trazodone And Xanax: Side Effects

Mixing Xanax and Trazodone can increase the side effects of both medicines which can affect you mentally and physically.

Physical Side effects are drowsiness, dry mouth, muscle aches, sweating, diarrhea, vomiting, constipation, decreased blood pressure, weight changes, blurred vision, speech problems, headache, difficulty urinating, and sore joints.

Mental side effects are anxiety, nightmares, sleepiness, irritability, trouble with balance or coordination, decreased concentration, nervousness, and suicidal thoughts.

Trazodone And Xanax: Precaution & Warning

Taking Xanax and trazodone requires specific precautions due to the potential for interactions, side effects, and health risks. Some important precautions are:

  • Consult with your doctor or healthcare provider before taking this combination.
  • Avoid taking Trazodone, Xanax and alcohol together. Also, don’t mix other benzo, and CNS depressants when taking both medicines.
  • Strictly follow the prescribed dosage which is provided by your doctor.
  • Respect the duration of these combined medicines.
  • Monitor your Side effects and report them to your doctor.
  • Do not stop them abruptly
  • Try your best to avoid activities that require your alertness.
  • Trazodone and Xanax for sleep: Never take them together before bed it causes sleep paralysis.
  • Keep your follow-up appointments with your doctor or healthcare provider to monitor your progress.

The feeling of Trazodone and Xanax high caused by the high sterolin level in the body. Always follow the precautions and guidance provided by your healthcare expert to ensure the safety of trazodone & Xanax use.

Signs Of Xanax And Trazodone Abuse

We all know that it is very difficult to spot the signs of medicine abuse. If you want to know the signs of Xanax and trazodone abuse then read the below symptoms, it may help you.

  • social isolation
  • issues with money
  • difficulty concentrating
  • stories that don’t add up
  • mental focus on medication
  • defensive attitude about prescription drugs
  • signs of dependence and withdrawal symptoms

If you see any of the signs in you or your loved one then immediately contact your doctor for treatment of Xanax And Trazodone Abuse.

Can You Take Trazodone With Xanax?

Doctors or healthcare professionals may prescribe Trazodone and Xanax together, carefully monitoring the dosage and response to treatment. Both medicines have sedative properties and trazodone has a lower half-life than Xanax. It can also heighten the risk of respiratory depression, particularly if taken in high doses or by individuals with underlying respiratory or cardiovascular conditions. Always consult with a healthcare professional or pharmacist before combining these medications. They can check your health condition, medical history, age, and weight and provide personalized advice based on your needs. Never self-adjust these medications without proper medical guidance.

Need Help:

We provide all possible information about Trazodone And Xanax. If you need a second opinion then consult with your doctor. Both medicines are very effective in individual use. Never combine them without a doctor’s permission. If you need any help related to this topic then feel free to contact us we provide the best solution to solve your problem. We hope that you and your loved one live a healthy and carefree life.