Anxiety may cause muscle tension, nervousness, and insomnia. If you have difficulty relaxing and sleeping then Anti-anxiety medicine can relieve anxiety symptoms. But some people mix over-the-counter medicine like Melatonin with anti-anxiety drugs like Xanax for better effect. Today we look at what Melatonin And Xanax medicines are, their uses, work, and whether we can mix them or not.

Xanax And Melatonin

What is Melatonin?— Melatonin is a hormone produced naturally by the pineal gland in the brain in response to darkness and light. It plays a role in regulating the sleep-wake cycle and is commonly used as a sleep aid. Melatonin supplements are available over-the-counter and are often used to treat insomnia, sleep disorders, and common symptoms of anxiety. It works by signaling to the body that it is time to sleep, helping to regulate the sleep-wake cycle.

What is Xanax?— Xanax also known by its generic name Alprazolam, is an FDA-approved prescription medicine that belongs to the class of drugs called benzodiazepines. It is used to treat anxiety, Panic Disorders, and insomnia. This medicine works by enhancing the activity of a neurotransmitter called GABA in the brain which leads to reduced anxiety and creates a calming and sedative effect.

Is Melatonin Like Xanax

Melatonin is not like Xanax. Although they both have sedative properties, they have different uses and mechanisms of action. Now we discuss all the similarities and differences between them so we have a better understanding that they are not alike.


Alprazolam and Melatonin have fewer similarities between them.

  • Increase Sedative Effect: Both Xanax and melatonin have sedative properties, meaning they can help promote relaxation and induce sleepiness.
  • Sleep Aids: Melatonin is commonly used as a sleep aid. It regulates sleep patterns and can help induce sleep when taken as a supplement. But Xanax is not primarily used as a sleep aid, it can help induce sleep with anxiety and panic orders who have trouble sleeping.
  • Side Effects: Remember taking them together can increase the side effects of the medicines. Common alprazolam and melatonin side effects are Tiredness, Dizziness, Headache, Drowsiness, Stomach pain, and Depressed mood.
  • Others: Store both medicines in a cool and dry place away from sunlight and water.


Xanax and melatonin are different medications with differences in their primary purposes, mechanisms of action, regulation, and other factors. The key differences are:

  • Uses: Xanax is used to treat anxiety and panic attacks. It helps relieve anxiety symptoms and creates calming effects that promote relaxation. Melatonin is primarily used as a sleep aid and is commonly used to treat insomnia, regulate sleep patterns, and help them fall asleep.
  • Mechanism of action: Xanax works by increasing the activity of the neurotransmitter GABA in the brain which leads to creating a calming effect and reducing anxiety. Melatonin works by influencing the body’s internal clock, signaling when it is time to sleep. In other words, it helps regulate the sleep-wake cycle and does not have anxiolytic properties like Xanax.
  • Availability: Xanax is a prescription medicine and requires a doctor’s prescription to obtain. Melatonin is an OTC medication means it can be purchased without a prescription.
  • Addiction and Dependence: Xanax has a high potential for addiction and dependence. Xanax is classified as a controlled substance [Schedule IV] because of its potential for dependence and addiction. Melatonin has a lower chance of addiction and dependence.

Melatonin and Xanax are two different medicines. One is used for anxiety and the other is used for insomnia. So it is better to consult with a healthcare professional for personalized advice and guidance regarding medication use.

Mix Alprazolam With Melatonin

People always ask “Can I take Xanax and melatonin at the same time”. Mixing medications can have unpredictable effects and may increase the risk of side effects or interactions. Under the guidance and supervision of healthcare professionals, you can take this combination. Both have sedative effects that influence your sleep patterns. Here we discuss some potential outcomes and concerns associated with combining these two substances.

  • Heightened sedation: Both medicines have sedative effects, so combining them may intensify these effects. It can impact your ability to function safely and alertly.
  • Enhanced Side Effects: combining melatonin and Xanax can enhance the side effects of the medicine such as excessive drowsiness, confusion, and impaired coordination.
  • Interaction: Xanax and melatonin interaction may also have an impact on the effectiveness and safety of each medication.
  • Dependence: Xanax has a higher potential for dependence and addiction. Mixing it with melatonin can increase the risk of dependence on Xanax.
  • Health Risk: It depends on various factors like age, weight, respective doses administered, current used medication, and medical history. So before taking any medicines consult with your doctor.
  • Overdose: The higher dose of these medicines can cause overdose, respiratory depression, coma, or death.

If you are taking alprazolam or melatonin for a specific condition, it’s always a good idea to talk to your doctor or pharmacist to understand the most appropriate and safe usage for your medicines to ensure your safety and well-being.

Drug Interaction: Melatonin and Xanax

Two or more drugs or between a drug and a food, beverage, or supplement reaction is known as a Drug interaction. Here we discuss drug, food, and disease interaction with Xanax and Melatonin.

  • Drug & medicine interaction: Xanax and Melatonin may interact with other medicines. They may affect the effect of medicines.
    • anti-depressants — fluoxetine, fluvoxamine, nefazodone
    • Antibiotics — erythromycin, rapamycin
    • Antifungals — ketoconazole
    • anti-HIV drugs — delavirdine
    • pain killers— morphine, codeine, dihydrocodeine, buprenorphine
  • Drug & Food Interaction: We all know that Xanax and alcohol are a deadly combination. Using foods like alcohol or grapefruit with this combination can increase side effects like sleepiness or slowed breathing. Always avoid consuming them together.

It’s best to avoid Xanax and melatonin taken together. Self-medicating or combining medications without professional guidance can be risky and may lead to adverse effects. Always follow your doctor or healthcare professional’s advice or instructions.

Safety Advice:

Xanax and Melatonin is a different medication. Mixing them together can increase the side effects and risks of medicine. Following safety advice can minimize the risk of dangerous situations and side effects. Some advice is:

  • Do not consume alcohol with this combination.
  • During pregnancy and breastfeeding avoid taking these medications because it can cause harm to the newborn baby.
  • After taking this combination do not drive.
  • Elderly People carefully take these medicines
  • Liver and kidney disease patients take these medicines together with caution
  • Before giving these medicines consult with a child specialist
  • Do not take this for a long time.
  • Keep a fixed time to go to bed and wake up.
  • Strictly follow all instructions given by your doctor and healthcare provider.

Before combining any medicines together, especially for those who have health issues consult with your doctor or healthcare expert. They can provide individualized guidance to ensure your safety and well-being. You can contact us we help to solve your problems and you can live a happy and carefree life.

Questions & Answers

How long after Xanax can you take Melatonin?

Xanax starts to work within 5 to 10 minutes after taking the pill and its effects last for 4-6 hours. The timing of when to take melatonin after using Xanax should be determined by your healthcare provider. It is generally advisable to consult with a doctor or pharmacist for personalized guidance based on your specific condition, medication dosage, and overall health.

Can you take Melatonin with Xanax?

Combining melatonin and alprazolam should be done with caution and under the guidance of a doctor or healthcare professional. The use of these medications together can increase sedation, respiratory depression, and other side effects.

It is always recommended to consult with your doctor or pharmacist before starting any new medications or combining medications. They will consider potential interactions, side effects, and individual factors to ensure your safety and well-being.